Nana Quame at a very tender age started-performing in talent show despite his extremely young age he won a talent show on national television doing renditions of Kojo Antwi songs. Kojo Antwi spotted the talent in Nana Quame so he retained him under his fold. Nana Quame featured in various hit songs in the mid 1990s including Ma Asan Aba by Akyeame, Philomena by Tic Tac as well as the mega hit, Tom & Jerry by Kojo Antwi.
Odo shock, which was a hit, took the singer to another level. He mounted stages alongside big Artists in Ghana and UK. Nana Quame has to his credit successful shows such as Loud In Accra 2000, he was the first Ghanaian to perform at the Carnival 2000 in UK and Ghana Independence Day Celebration UK, Miss Ghana 2001(Ghana), Africa Durb(UK)